SINGLE-CELL RNA SEQUENCING UNVEILS THE ACTIVATION OF EGR1-ATF3 SIGNALING IN EGR1 + MUSCLE STEM CELLS DURING HUMAN PARAVERTEBRAL MUSCLE DEGENERATION

Single-cell RNA sequencing unveils the activation of EGR1-ATF3 signaling in EGR1 + muscle stem cells during human paravertebral muscle degeneration

Background: Paravertebral muscles (PVM) degeneration (PMD) is closely associated with low back pain.Muscle stem cells (MuSCs) can promote muscle regeneration and repair.However, our understanding of the cellular composition of PVM and the key genes-mediated MuSCs functions is limited.Methods: We analyzed cells heterogeneity and identified key genes

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Abundance and Compositions of B-Vitamin-Producing Microbes in the Mammalian Gut Vary Based on Feeding Strategies

ABSTRACT Mammals maintain close associations with gut microbes that provide numerous nutritional benefits, including vitamin synthesis.While most mammals obtain sufficient vitamins from their diets, deficiencies in various B vitamins (biotin, cobalamin, riboflavin, thiamine, etc.) are reported in captive animals.Biomedical and agricultural research

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Incorporating energy justice throughout clean-energy R&D5 in the United States: A review of outcomes and opportunities

Summary: It is widely acknowledged that a successful clean-energy transition is instrumental to climate change mitigation.However, clean-energy researchers and engineers rarely address the degree to which the success and consequences of the transition depend on its incorporation of equity and justice principles.In this review, G Racing we draw on i

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